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KMID : 1007520190280020563
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Food Science and Biotechnology
2019 Volume.28 No. 2 p.563 ~ p.568
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Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice
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Kim Jung-Hyun
Hyun Soo-Wang
Lee Ik-Soo
Jo Kyu-Hyung
Kim Young-Sook
Kim Jin-Sook
Kim Chan-Sik
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Abstract
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The Aster koraiensis extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose tolerance tests (OGTTs). In a long-term efficacy study, 4 weeks of oral ASKO treatment significantly attenuated blood glucose levels during OGTTs in diet-induced obese (DIO) mice. ASKO also enhanced plasma insulin levels after glucose loading, leading to a reduction in blood glucose levels. In addition, ASKO normalized glucose transporter-4 mRNA expression in the muscles of DIO mice. These results indicate that ASKO has postprandial glucose-lowering effects and could be beneficial in the management of prediabetes or type 2 diabetes mellitus.
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KEYWORD
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Aster koraiensis, Glucose transporter, Postprandial glucose, Type 2 diabetes mellitus
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